Vitamin E and selenium co-supplementation attenuates oxidative stress in haemodialysis patients receiving intra-dialysis iron infusion.
نویسندگان
چکیده
erative endarteritis were found in the kidney tissue, suggesting intravenous drug addiction in the kidney donor (Figure 1D). Follow-up quantitative Polymerase chain reaction (PCR) for cytomegalovirus (CMV) revealed 65.000 copies/ml. Liposomal amphotericin B, therapy for nontuberculous mycobacteriosis and ganciclovir were added to the therapeutic regime. The patient’s condition did not improve and despite all efforts, he died 102 days after the transplantation. This case demonstrates an unfortunate combination of bacterial, fungal and parasitic infections (CMV was reactivation) following kidney transplantation from a living unrelated donor in India. To the authors’ knowledge, 43 cases of post-transplant malaria have been reported [2–4]. During his stay in India, our patient remained in New Delhi and was therefore not exposed to malaria-bearing mosquitoes, so the most likely source of malaria was the allograft. It is highly likely that deep mycosis (A. tereus, Mucor spp.) and M. fortuitum were transmitted by the renal allograft as well. Renal mucormycosis, sharing similarities with our case, has previously been reported in a patient actively using intravenous drugs [5]. Over half of all the renal transplant recipients in tropical countries develop a serious infection at some point in the post-transplant period and 20–40% of them succumb to these infections [1,6,7]. A multitude of factors (unhygienic conditions, hot and humid climate, scanty diagnostic techniques, etc.) contribute to this dismal outcome. In commercial transplantations, the primary objective of the medical team is often profit, and not necessarily the well-being of either donors or recipients.
منابع مشابه
Fatal Candida famata peritonitis complicating sclerosing peritonitis in a peritoneal dialysis patient.
vitamin C supplementation on oxidative stress and inflammation status in haemodialysis patients. Nephrol Dial Transplant 2005; 20: 1874–1879 2. You SA, Wang Q. Ferritin in atherosclerosis. Clin Chim Acta 2005; 357: 1–16 3. Puntarulo S. Iron, oxidative stress and human health. Mol Aspects Med 2005; 26: 299–312 4. Kletzmayr J, Horl WH. Iron overload and cardiovascular complications in dialysis pa...
متن کاملVitamin E attenuates oxidative stress induced by intravenous iron in patients on hemodialysis.
Intravenous iron application to anemic patients on hemodialysis leads to an "oversaturation" of transferrin. As a result, non-transferrin-bound, redox-active iron might induce lipid peroxidation. To test the hypothesis that vitamin E attenuates lipid peroxidation in patients receiving 100 mg of iron(III) hydroxide sucrose complex intravenously during a hemodialysis session, 22 patients were inv...
متن کاملAntioxidant status of elderly chronic renal patients treated by continuous ambulatory peritoneal dialysis.
BACKGROUND An oxidative stress has been reported in patients with chronic renal failure (CRF) treated by haemodialysis. To our knowledge, only scant information is available concerning CRF patients treated by continuous ambulatory peritoneal dialysis (CAPD) with regard to their redox and nutritional status. METHODS The oxidative stress and the biological nutritional status were evaluated in 2...
متن کاملEnhanced oxidative stress in haemodialysis patients receiving intravenous iron therapy.
BACKGROUND Iron balance is critical for adequate erythropoiesis and there remains much debate concerning the optimal timing and dosage of iron therapy for haemodialysis patients receiving recombinant human erythropoietin therapy. METHODS In this study, we examined the influence of baseline ferritin level and intravenous infusion of 100 mg ferric saccharate on the oxidative status of the patie...
متن کاملEffects of oral vitamin C supplementation on oxidative stress and inflammation status in haemodialysis patients.
BACKGROUND There is increasing evidence for the presence of oxidative stress and vitamin C deficiency in dialysis patients. Limited data, however, are available regarding the effects of vitamin C supplementation on oxidative stress and inflammation markers in such patients. METHODS We ran a prospective, randomized, open-label trial to assess the effects of oral vitamin C supplementation (250 ...
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ورودعنوان ژورنال:
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
دوره 22 3 شماره
صفحات -
تاریخ انتشار 2007